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| カタログ番号 | HF517014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-BCAR3 Polyclonal Antibody (HF517014) is a rabbit polyclonal antibody detecting BCAR3 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human BCAR3 (Glu533-Leu825). | ||||||||
| ターゲット | SH2 domain-containing protein 3B, Novel SH2-containing protein 2, SH2D3B, NSP2, Breast cancer anti-estrogen resistance protein 3, BCAR3 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O75815 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Breast cancer anti-estrogen resistance protein 3 (BCAR3) is a ~92 kDa protein. Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers. Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis. Promotes insulin-mediated membrane ruffling. In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1. Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity. 1. Oh, MJ. et al. (2013) Biochemical and biophysical research communications 441, 911-6. PMID: 24216110 2. Rufanova, VA. et al. (2009) Journal of cellular physiology 219, 45-56. PMID: 19086031 3. Oh, MJ. et al. (2008) Biochemical and biophysical research communications 375, 430-4. PMID: 18722344 4. Mace, PD. et al. (2011) Nature structural & molecular biology 18, 1381-7. PMID: 22081014 | ||||||||
| 注意事項 | For research use only. |
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