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| カタログ番号 | HB447014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-BEND3 Polyclonal Antibody (HB447014) is a rabbit polyclonal antibody detecting BEN domain-containing protein 3; BEND3; KIAA1553 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant human BEND3 (Ser383-Val662). | ||||||||
| ターゲット | BEN domain-containing protein 3; BEND3; KIAA1553 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q5T5X7, Q6PAL0 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | BEN domain-containing protein 3 (BEND3) is a ~94 kDa protein. Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination. Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites. Stimulates the ERCC6L translocase and ATPase activities. 1. Sathyan, KM. et al. (2011) Journal of cell science 124, 3149-63. PMID: 21914818 2. Khan, A. et al. (2015) Proceedings of the National Academy of Sciences of the United States of America 112, 8338-43. PMID: 26100909 3. Pitchai, GP. et al. (2017) Nucleic acids research 45, 11413-11424. PMID: 28977671 | ||||||||
| 注意事項 | For research use only |
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