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| カタログ番号 | HT337014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-BIRC5 Polyclonal Antibody (HT337014) is a rabbit polyclonal antibody detecting BIRC5 in ELISA, IHC, WB. Suitable for Human, Dog, Cat, Bovine, and Cavia porcellus.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human BIRC5 (Met1-Asp142). | ||||||||
| ターゲット | BIRC5, IAP4, Apoptosis inhibitor survivin, Apoptosis inhibitor 4, API4, Baculoviral IAP repeat-containing protein 5 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O15392 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Baculoviral IAP repeat-containing protein 5 (BIRC5) is a ~16 kDa protein. Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. 1. Habtemichael, N. et al. (2010) Molecular and cellular neurosciences 45, 297-305. PMID: 20627126 2. Knauer, SK. et al. (2010) Cell death & disease 1, e51. PMID: 21364656 3. Liu, Y. et al. (2015) The Journal of biological chemistry 290, 11843-52. PMID: 25778398 4. Kamran, M. et al. (2017) Oncogenesis 6, e298. PMID: 28218735 5. Li, F. et al. (1998) Nature 396, 580-4. PMID: 9859993 6. Vong, QP. et al. (2005) Science (New York, N.Y.) 310, 1499-504. PMID: 16322459 7. Wang, H. et al. (2010) The Journal of biological chemistry 285, 36129-37. PMID: 20826784 8. Yamagishi, Y. et al. (2010) Science (New York, N.Y.) 330, 239-43. PMID: 20929775 9. Xia, F. et al. (2008) Molecular and cellular biology 28, 5299-311. PMID: 18591255 | ||||||||
| 注意事項 | For research use only. |
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