Anti-BLK Polyclonal Antibody (HW362014)

Name: Anti-BLK Polyclonal Antibody
Brand: abinScience
SKU: HW362014
Price: 168 USD
Availability: InStock

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Aperçu

Numéro de catalogue

HW362014

Description

Anti-BLK Polyclonal Antibody (HW362014) is a rabbit polyclonal antibody detecting BLK in ELISA, IHC, WB. Suitable for Human and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactivité des espèces

Human, Mouse

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human BLK (Leu241-Tyr494).

Cible

Tyrosine-protein kinase Blk, BLK, p55-Blk, B lymphocyte kinase

Purification

Purified by antigen affinity column.

Numéro d'accès

P51451

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Tyrosine-protein kinase Blk is a ~57 kDa protein. Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr-207'.

1. Bewarder, N. et al. (1996) Molecular and cellular biology 16, 4735-43. PMID: 8756631

2. Borowiec, M. et al. (2009) Proceedings of the National Academy of Sciences of the United States of America 106, 14460-5. PMID: 19667185

3. Liu, H. et al. (2018) Nature 563, 131-136. PMID: 30356214

Note

For research use only.

Images

Reférences

Fiche technique

Anti-BLK Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

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