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| カタログ番号 | HW362014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-BLK Polyclonal Antibody (HW362014) is a rabbit polyclonal antibody detecting BLK in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human BLK (Leu241-Tyr494). | ||||||||
| ターゲット | Tyrosine-protein kinase Blk, BLK, p55-Blk, B lymphocyte kinase | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P51451 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Tyrosine-protein kinase Blk is a ~57 kDa protein. Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr-207'. 1. Bewarder, N. et al. (1996) Molecular and cellular biology 16, 4735-43. PMID: 8756631 2. Borowiec, M. et al. (2009) Proceedings of the National Academy of Sciences of the United States of America 106, 14460-5. PMID: 19667185 3. Liu, H. et al. (2018) Nature 563, 131-136. PMID: 30356214 | ||||||||
| 注意事項 | For research use only. |
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