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| カタログ番号 | HB818014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-BLVRB Polyclonal Antibody (HB818014) is a rabbit polyclonal antibody detecting BLVRB in ELISA, IHC, WB. Suitable for Human, Mouse, and Bovine.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human BLVRB (Ala2-Gln206). | ||||||||
| ターゲット | FR, Green heme-binding protein, BLVRB, Flavin reductase (NADPH), FLR, NADPH-flavin reductase, GHBP, Biliverdin-IX beta-reductase, NADPH-dependent diaphorase, BVR-B, Biliverdin reductase B | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P30043 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Flavin reductase (NADPH) (BLVRB) is a ~22 kDa protein. Enzyme that can both act as a NAD(P)H-dependent reductase and a S-nitroso-CoA-dependent nitrosyltransferase. Promotes fetal heme degradation during development. Also expressed in adult tissues, where it acts as a regulator of hematopoiesis, intermediary metabolism (glutaminolysis, glycolysis, TCA cycle and pentose phosphate pathway) and insulin signaling. Has a broad specificity oxidoreductase activity by catalyzing the NAD(P)H-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to fetal heme catabolism by catalyzing reduction of biliverdin IXbeta into bilirubin IXbeta in the liver. 1. Cunningham, O. et al. (2000) The Biochemical journal 345 Pt 2, 393-9. PMID: 10620517 2. Smith, LJ. et al. (2008) The Biochemical journal 411, 475-84. PMID: 18241201 3. Wu, S. et al. (2016) Blood 128, 699-709. PMID: 27207795 4. Zhou, HL. et al. (2023) Cell 186, 5812-5825.e21. PMID: 38056462 5. Yamaguchi, T. et al. (1994) The Journal of biological chemistry 269, 24343-8. PMID: 7929092 6. Cunningham, O. et al. (2000) The Journal of biological chemistry 275, 19009-17. PMID: 10858451 7. Li, Z. et al. (2018) The Biochemical journal 475, 1211-1223. PMID: 29500232 | ||||||||
| 注意事項 | For research use only. |
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