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Anti-BMI1 Polyclonal Antibody (HW616014)

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Aperçu
Numéro de catalogueHW616014
Description
Anti-BMI1 Polyclonal Antibody (HW616014) is a rabbit polyclonal antibody detecting BMI1 in ELISA, IHC, WB. Suitable for Human, Mouse, Bovine, Cat, and Chicken.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Reactivité des espècesHuman, Mouse
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Human BMI1 (Glu152-Ile289).
Cible RING finger protein 51, BMI1, RNF51, Polycomb complex protein BMI-1, Polycomb group RING finger protein 4, PCGF4
Purification Purified by antigen affinity column.
Numéro d'accès P35226
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

Polycomb complex protein BMI-1 (BMI1) is a ~36 kDa protein. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2.

1. Wang, H. et al. (2004) Nature 431, 873-8. PMID: 15386022
2. Cao, R. et al. (2005) Molecular cell 20, 845-54. PMID: 16359901
3. Li, Z. et al. (2006) The Journal of biological chemistry 281, 20643-9. PMID: 16714294
4. Bentley, ML. et al. (2011) The EMBO journal 30, 3285-97. PMID: 21772249
5. McGinty, RK. et al. (2014) Nature 514, 591-6. PMID: 25355358
6. Taherbhoy, AM. et al. (2015) Nature communications 6, 7621. PMID: 26151332
7. Gray, F. et al. (2016) Nature communications 7, 13343. PMID: 27827373
Note For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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Anti-BMI1 Polyclonal Antibody

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