Anti-BMP2 Polyclonal Antibody (HY576014)

Name: Anti-BMP2 Polyclonal Antibody
Brand: abinScience
SKU: HY576014
Price: 168 USD
Availability: InStock

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Prix(USD) :

Spécification :

50ug
100ug

Nombre :

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Aperçu
Images
Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HY576014

Reactivité des espèces

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human BMP2 (Gln283-Arg396).

Cible

BMP-2, BMP2A, Bone morphogenetic protein 2A, Bone morphogenetic protein 2, BMP2, BMP-2A

Purification

Purified by antigen affinity column.

Numéro d'accès

P12643

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Bone morphogenetic protein 2 (BMP2) is a ~44 kDa protein. Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis. Induces cartilage and bone formation. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes.

1. Lavery, K. et al. (2008) The Journal of biological chemistry 283, 20948-58. PMID: 18436533

2. Tanaka, K. et al. (2014) Calcified tissue international 94, 454-64. PMID: 24362451

3. Seeherman, HJ. et al. (2019) Science translational medicine 11. PMID: 31019025

4. Wozney, JM. et al. (1988) Science (New York, N.Y.) 242, 1528-34. PMID: 3201241

5. Keller, S. et al. (2004) Nature structural & molecular biology 11, 481-8. PMID: 15064755

6. Weber, D. et al. (2007) BMC structural biology 7, 6. PMID: 17295905

7. Liu, F. et al. (1995) Molecular and cellular biology 15, 3479-86. PMID: 7791754

8. Wang, CY. et al. (2020) Blood 135, 453-456. PMID: 31800957

9. Tsukahara, S. et al. (2006) The Biochemical journal 398, 595-603. PMID: 16771708

Note

For research use only.

Images

Reférences

Fiche technique

Anti-BMP2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

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