

| Numéro de catalogue | HW413014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-BMX Polyclonal Antibody (HW413014) is a rabbit polyclonal antibody detecting BMX in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Reactivité des espèces | Human | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human BMX (Glu287-Gly523). | ||||||||
| Cible | BMX, Epithelial and endothelial tyrosine kinase, Cytoplasmic tyrosine-protein kinase BMX, ETK, Bone marrow tyrosine kinase gene in chromosome X protein, NTK38 | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | P51813 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | Cytoplasmic tyrosine-protein kinase BMX is a ~78 kDa protein. Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. | ||||||||
| Note | For research use only. |
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