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| カタログ番号 | BY485014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Bovine ISG15 Polyclonal Antibody (BY485014) is a rabbit polyclonal antibody detecting ISG15 in ELISA, IHC, WB. Suitable for Bovine.
Highlights
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| 種反応性 | Bovine | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Bovine ISG15 (Met1-Gly154). | ||||||||
| ターゲット | Interferon-induced 17 kDa protein, G1P2, hUCRP, Ubiquitin-like protein ISG15, IP17, UCRP, ISG15, Ubiquitin cross-reactive protein, Interferon-induced 15 kDa protein, | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 純度 | >95% as determined by SDS-PAGE. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O02741 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Ubiquitin-like protein ISG15 is a ~17 kDa protein. Ubiquitin-like protein which plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein. ISGylation involves a cascade of enzymatic reactions involving E1, E2, and E3 enzymes which catalyze the conjugation of ISG15 to a lysine residue in the target protein. Exhibits antiviral activity towards both DNA and RNA viruses. The secreted form of ISG15 can: induce natural killer cell proliferation, augment lymphokine-activated-killer (LAK) activity, induce dendritic cell maturation, act as a chemotactic factor for neutrophils and act as a IFN-gamma-inducing cytokine playing an essential role in antimycobacterial immunity. The secreted form acts through the integrin ITGAL/ITGB2 receptor to initiate activation of SRC family tyrosine kinases including LYN, HCK and FGR which leads to secretion of IFNG and IL10; the interaction is mediated by ITGAL. 1. Johnson, GA. et al. (1998) Biology of reproduction 58, 898-904. PMID: 9546718 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-ISG15 polyclonal antibody at 1ug/mL on various samples.
Lane 1: HepG2 cell lysate
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