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| カタログ番号 | HA695014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-BRCC3 Polyclonal Antibody (HA695014) is a rabbit polyclonal antibody detecting Lys-63-specific deubiquitinase BRCC36; 3.4.19.-; BRCA1-A complex subunit BRCC36; BRCA1/BRCA2-containing complex subunit 3; BRCA1/BRCA2-containing complex subunit 36; BRISC complex subunit BRCC36; BRCC3; BRCC36; C6.1A; CXorf53 in ELISA, IHC, WB. Suitable for Human and Bovine.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant human BRCC3 (Val12-Thr223). | ||||||||
| ターゲット | Lys-63-specific deubiquitinase BRCC36; 3.4.19.-; BRCA1-A complex subunit BRCC36; BRCA1/BRCA2-containing complex subunit 3; BRCA1/BRCA2-containing complex subunit 36; BRISC complex subunit BRCC36; BRCC3; BRCC36; C6.1A; CXorf53 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P46736, A5PJP6 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Lys-63-specific deubiquitinase BRCC36 is a ~36 kDa protein. Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. 1. Cooper, EM. et al. (2009) The EMBO journal 28, 621-31. PMID: 19214193 2. Feng, L. et al. (2010) The Journal of biological chemistry 285, 30982-8. PMID: 20656690 3. Zheng, H. et al. (2013) Cell reports 5, 180-93. PMID: 24075985 4. Zeqiraj, E. et al. (2015) Molecular cell 59, 970-83. PMID: 26344097 5. Dong, Y. et al. (2003) Molecular cell 12, 1087-99. PMID: 14636569 6. Chen, X. et al. (2006) Cancer research 66, 5039-46. PMID: 16707425 7. Sobhian, B. et al. (2007) Science (New York, N.Y.) 316, 1198-202. PMID: 17525341 9. Shao, G. et al. (2009) Genes & development 23, 740-54. PMID: 19261746 10. Feng, L. et al. (2009) Genes & development 23, 719-28. PMID: 19261748 | ||||||||
| 注意事項 | For research use only |
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