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Anti-C8B Polyclonal Antibody (HY246014)

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Vista general
Número de catálogoHY246014
Descripción
Anti-C8B Polyclonal Antibody (HY246014) is a rabbit polyclonal antibody detecting C8B in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactividad de especiesHuman
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human C8B (Cys162-His504).
Objetivo C8B, Complement component C8 beta chain, Complement component 8 subunit beta
Purificación Purified by antigen affinity column.
Número de acceso P07358
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Complement component C8 beta chain (C8B) is a ~66 kDa protein. Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C8B, together with C8A and C8G, inserts into the target membrane, but does not form pores by itself. During MAC assembly, associates with C5b, C6 and C7 to form the C5b8 intermediate complex that inserts into the target membrane and traverses the bilayer increasing membrane rigidity.

1. Hadders, MA. et al. (2012) Cell reports 1, 200-7. PMID: 22832194
2. Serna, M. et al. (2016) Nature communications 7, 10587. PMID: 26841837
3. Sharp, TH. et al. (2016) Cell reports 15, 1-8. PMID: 27052168
4. Menny, A. et al. (2018) Nature communications 9, 5316. PMID: 30552328
5. Steckel, EW. et al. (1980) The Journal of biological chemistry 255, 11997-2005. PMID: 7440581
6. Donado, CA. et al. (2025) Nature 641, 211-221. PMID: 39914456
7. Lan, F. et al. (2025) Nature 638, 490-498. PMID: 39814882
8. Steckel, EW. et al. (1983) The Journal of biological chemistry 258, 4318-24. PMID: 6833260
Nota For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-C8B Polyclonal Antibody

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