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Anti-C8G Polyclonal Antibody (HY588014)

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Aperçu
Numéro de catalogueHY588014
Description
Anti-C8G Polyclonal Antibody (HY588014) is a rabbit polyclonal antibody detecting C8G in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactivité des espècesHuman
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Human C8G (Lys39-Arg202).
Cible Complement component C8 gamma chain, C8G
Purification Purified by antigen affinity column.
Numéro d'accès P07360
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

Complement component C8 gamma chain (C8G) is a ~22 kDa protein. Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C8G, together with C8A and C8B, inserts into the target membrane, but does not form pores by itself. During MAC assembly, associates with C5b, C6 and C7 to form the C5b8 intermediate complex that inserts into the target membrane and traverses the bilayer increasing membrane rigidity.

1. Serna, M. et al. (2016) Nature communications 7, 10587. PMID: 26841837
2. Sharp, TH. et al. (2016) Cell reports 15, 1-8. PMID: 27052168
3. Menny, A. et al. (2018) Nature communications 9, 5316. PMID: 30552328
4. Donado, CA. et al. (2025) Nature 641, 211-221. PMID: 39914456
5. Lan, F. et al. (2025) Nature 638, 490-498. PMID: 39814882
6. Steckel, EW. et al. (1983) The Journal of biological chemistry 258, 4318-24. PMID: 6833260
Note For research use only.
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Reférences
Fiche technique
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-C8G Polyclonal Antibody

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