

| Número de catálogo | HY033014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Descripción |
Anti-C9 Polyclonal Antibody (HY033014) is a rabbit polyclonal antibody detecting C9 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Reactividad de especies | Human | ||||||||
| Aplicaciones | ELISA, IHC, WB | ||||||||
| Especie huésped | Rabbit | ||||||||
| Clonalidad | Polyclonal | ||||||||
| Isotipo | IgG | ||||||||
| Inmunógeno | E. coli - derived recombinant Human C9 (Gln22-His265). | ||||||||
| Objetivo | Complement component C9, C9 | ||||||||
| Purificación | Purified by antigen affinity column. | ||||||||
| Número de acceso | P02748 | ||||||||
| Forma | Liquid | ||||||||
| Buffer de almacenamiento | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote. |
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| Información de uso del producto |
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| Estabilidad y almacenamiento | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Fondo | Complement component C9 (Complement C9) is a ~63 kDa protein. Pore-forming component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Constitutes the pore-forming subunit of the MAC complex: during MAC assembly, C9 associates with the C5b8 intermediate complex, and polymerizes to complete the pore. 1. Hadders, MA. et al. (2012) Cell reports 1, 200-7. PMID: 22832194 2. Serna, M. et al. (2016) Nature communications 7, 10587. PMID: 26841837 3. Dudkina, NV. et al. (2016) Nature communications 7, 10588. PMID: 26841934 4. Sharp, TH. et al. (2016) Cell reports 15, 1-8. PMID: 27052168 5. Menny, A. et al. (2018) Nature communications 9, 5316. PMID: 30552328 6. Podack, ER. et al. (1982) The Journal of experimental medicine 156, 268-82. PMID: 6177822 7. Lassiter, HA. et al. (1997) Pediatric research 42, 128-36. PMID: 9212048 8. Witzel-Schlömp, K. et al. (1998) Immunogenetics 48, 144-7. PMID: 9634479 9. Donado, CA. et al. (2025) Nature 641, 211-221. PMID: 39914456 10. Lan, F. et al. (2025) Nature 638, 490-498. PMID: 39814882 | ||||||||
| Nota | For research use only. |
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