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| カタログ番号 | HY033014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-C9 Polyclonal Antibody (HY033014) is a rabbit polyclonal antibody detecting C9 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human C9 (Gln22-His265). | ||||||||
| ターゲット | Complement component C9, C9 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P02748 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Complement component C9 (Complement C9) is a ~63 kDa protein. Pore-forming component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Constitutes the pore-forming subunit of the MAC complex: during MAC assembly, C9 associates with the C5b8 intermediate complex, and polymerizes to complete the pore. 1. Hadders, MA. et al. (2012) Cell reports 1, 200-7. PMID: 22832194 2. Serna, M. et al. (2016) Nature communications 7, 10587. PMID: 26841837 3. Dudkina, NV. et al. (2016) Nature communications 7, 10588. PMID: 26841934 4. Sharp, TH. et al. (2016) Cell reports 15, 1-8. PMID: 27052168 5. Menny, A. et al. (2018) Nature communications 9, 5316. PMID: 30552328 6. Podack, ER. et al. (1982) The Journal of experimental medicine 156, 268-82. PMID: 6177822 7. Lassiter, HA. et al. (1997) Pediatric research 42, 128-36. PMID: 9212048 8. Witzel-Schlömp, K. et al. (1998) Immunogenetics 48, 144-7. PMID: 9634479 9. Donado, CA. et al. (2025) Nature 641, 211-221. PMID: 39914456 10. Lan, F. et al. (2025) Nature 638, 490-498. PMID: 39814882 | ||||||||
| 注意事項 | For research use only. |
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