Anti-CALCRL Polyclonal Antibody (HS841014)

Name: Anti-CALCRL Polyclonal Antibody
Brand: abinScience
SKU: HS841014
Price: 168 USD
Availability: InStock

データシート製品共有情報コピー

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概要
イメージ
参考文献
データシート
SDS

概要

カタログ番号

HS841014

説明

Anti-CALCRL Polyclonal Antibody (HS841014) is a rabbit polyclonal antibody detecting CALCRL in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Pig.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

種反応性

Human

アプリケーション

ELISA, IHC, WB

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

免疫原

E. coli - derived recombinant Human CALCRL (Glu23-Glu133).

ターゲット

CGRP type 1 receptor, CGRPR, Calcitonin receptor-like receptor, CALCRL, Calcitonin gene-related peptide type 1 receptor

精製

Purified by antigen affinity column.

アクセッション番号

Q16602

形態

Liquid

保存バッファー

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。

製品使用情報

アプリケーション	希釈
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

安定性と保存

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Calcitonin gene-related peptide type 1 receptor (CALCRL) is a ~52 kDa protein. G protein-coupled receptor which specificity is determined by its interaction with receptor-activity-modifying proteins (RAMPs). Together with RAMP1, form the receptor complex for calcitonin-gene-related peptides CALCA/CGRP1 and CALCB/CGRP2. Together with RAMP2 or RAMP3, function as receptor complexes for adrenomedullin (ADM and ADM2). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway.

1. Liang, YL. et al. (2020) ACS pharmacology & translational science 3, 263-284. PMID: 32296767

2. Josephs, TM. et al. (2021) Science (New York, N.Y.) 372. PMID: 33602864

3. Aiyar, N. et al. (1996) The Journal of biological chemistry 271, 11325-9. PMID: 8626685

4. McLatchie, LM. et al. (1998) Nature 393, 333-9. PMID: 9620797

注意事項

For research use only.

イメージ

参考文献

データシート

Anti-CALCRL Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

組換えタンパク質

抗体

アッセイキット

Anti-CALCRL Polyclonal Antibody (HS841014)

概要

イメージ

参考文献

データシート

SDS

クイックアクセス

お問い合わせ