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| カタログ番号 | HB822033 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | IHC, WB | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | L112/49 | ||||
| ターゲット | CNR1, CB1, CANN6, CB-R, CNR, Cannabinoid receptor 1 | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | P21554,P47746,P20272 | ||||
| RRID | Anti-Cannabinoid receptor 1 Antibody (L112/49) (abinScience Cat# HB822033, RRID:AB_3728156) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Cannabinoid receptor 1 (CNR1/CB1) is a ~52 kDa protein. G-protein coupled receptor for endogenous cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG), as well as phytocannabinoids, such as delta(9)-tetrahydrocannabinol (THC). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while decreases respiration at high doses. 1. Ryberg, E. et al. (2005) FEBS letters 579, 259-64. PMID: 15620723 2. Hua, T. et al. (2016) Cell 167, 750-762.e14. PMID: 27768894 3. Shao, Z. et al. (2016) Nature 540, 602-606. PMID: 27851727 4. Yang, X. et al. (2022) Nature chemical biology 18, 831-840. PMID: 35637350 5. Gérard, CM. et al. (1991) The Biochemical journal 279 ( Pt 1), 129-34. PMID: 1718258 6. Oddi, S. et al. (2012) British journal of pharmacology 165, 2635-51. PMID: 21895628 7. Niehaus, JL. et al. (2007) Molecular pharmacology 72, 1557-66. PMID: 17895407 8. Jourdan, T. et al. (2013) Nature medicine 19, 1132-40. PMID: 23955712 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Cannabinoid receptor 1 Antibody (L112/49)
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