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| カタログ番号 | HW822014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-CAPZA1 Polyclonal Antibody (HW822014) is a rabbit polyclonal antibody detecting CAPZA1 in ELISA, IHC, WB. Suitable for Human, Mouse, Dog, Cat, and Aotus nancymaae.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CAPZA1 (Met1-Ala286). | ||||||||
| ターゲット | CapZ alpha-1, CAPZA1, F-actin-capping protein subunit alpha-1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P52907 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | F-actin-capping protein subunit alpha-1 (CAPZA1) is a ~32 kDa protein. F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions. Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules. 1. Elbediwy, A. et al. (2012) The Journal of cell biology 198, 677-93. PMID: 22891260 | ||||||||
| 注意事項 | For research use only. |
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