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| カタログ番号 | HB268014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-CASP14 Polyclonal Antibody (HB268014) is a rabbit polyclonal antibody detecting CASP14 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CASP14 (Met1-Gln242). | ||||||||
| ターゲット | CASP14, CASP-14, Caspase-14 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P31944 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Caspase-14 (CASP14) is a ~27 kDa protein. Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum. Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin. In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF. 1. Fischer, H. et al. (2004) FEBS letters 577, 446-50. PMID: 15556625 2. Park, K. et al. (2006) Biochemical and biophysical research communications 347, 941-8. PMID: 16854378 3. Hibino, T. et al. (2010) Journal of cellular biochemistry 109, 487-97. PMID: 19960512 4. Beasley, S. et al. (2014) BioMed research international 2014, 417986. PMID: 25121097 5. Yamamoto-Tanaka, M. et al. (2014) Cell death & disease 5, e1181. PMID: 24743736 | ||||||||
| 注意事項 | For research use only. |
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