

| Numéro de catalogue | HW804014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-CASP2 Polyclonal Antibody (HW804014) is a rabbit polyclonal antibody detecting CASP2 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| Reactivité des espèces | Human, Mouse, Rat | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human CASP2 (Gly334-Thr452). | ||||||||
| Cible | Protease ICH-1, ICH1, Neural precursor cell expressed developmentally down-regulated protein 2, NEDD2, CASP-2, Caspase-2, CASP2, NEDD-2 | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | P42575 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | Caspase-2 (CASP2) is a ~50 kDa protein. Is a regulator of the cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress. 1. Droin, N. et al. (2000) Cancer research 60, 7039-47. PMID: 11156409 2. Tinel, A. et al. (2004) Science (New York, N.Y.) 304, 843-6. PMID: 15073321 3. Wang, L. et al. (1994) Cell 78, 739-50. PMID: 8087842 | ||||||||
| Note | For research use only. |



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