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| カタログ番号 | HX967014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-CASP7 Polyclonal Antibody (HX967014) is a rabbit polyclonal antibody detecting CASP7 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CASP7 (Ala24-Asp198). | ||||||||
| ターゲット | CASP7, ICE-LAP3, CASP-7, MCH3, Caspase-7, CMH-1, ICE-like apoptotic protease 3, Apoptotic protease Mch-3 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P55210 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Caspase-7 (CASP7) is a ~34 kDa protein. Thiol protease involved in different programmed cell death processes, such as apoptosis, pyroptosis or granzyme-mediated programmed cell death, by proteolytically cleaving target proteins. Has a marked preference for Asp-Glu-Val-Asp (DEVD) consensus sequences, with some plasticity for alternate non-canonical sequences. Its involvement in the different programmed cell death processes is probably determined by upstream proteases that activate CASP7. Acts as an effector caspase involved in the execution phase of apoptosis: following cleavage and activation by initiator caspases (CASP8, CASP9 and/or CASP10), mediates execution of apoptosis by catalyzing cleavage of proteins, such as CLSPN, PARP1, PTGES3 and YY1. Compared to CASP3, acts as a minor executioner caspase and cleaves a limited set of target proteins. 1. Chai, J. et al. (2001) Cell 104, 769-80. PMID: 11257230 2. Huang, Y. et al. (2001) Cell 104, 781-90. PMID: 11257231 3. Chai, J. et al. (2001) Cell 107, 399-407. PMID: 11701129 4. Hardy, JA. et al. (2004) Proceedings of the National Academy of Sciences of the United States of America 101, 12461-6. PMID: 15314233 5. Denault, JB. et al. (2006) Molecular cell 23, 523-33. PMID: 16916640 6. Young, JE. et al. (2007) The Journal of biological chemistry 282, 30150-60. PMID: 17646170 7. Walsh, JG. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 12815-9. PMID: 18723680 8. Hardy, JA. et al. (2009) The Journal of biological chemistry 284, 26063-9. PMID: 19581639 9. Fernandes-Alnemri, T. et al. (1995) Cancer research 55, 6045-52. PMID: 8521391 10. Lippke, JA. et al. (1996) The Journal of biological chemistry 271, 1825-8. PMID: 8567622 | ||||||||
| 注意事項 | For research use only. |
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