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| カタログ番号 | HC266014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-CASP8 Polyclonal Antibody (HC266014) is a rabbit polyclonal antibody detecting CASP8 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CASP8 (Ser217-Asp479). | ||||||||
| ターゲット | CAP4, MCH5, FADD-homologous ICE/ced-3-like protease, FLICE, Apoptotic cysteine protease, MORT1-associated ced-3 homolog, MACH, FADD-like ICE, ICE-like apoptotic protease 5, CASP8, CASP-8, Caspase-8, Apoptotic protease Mch-5 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q14790 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Caspase-8 (CASP8) is a ~55 kDa protein. Thiol protease that plays a key role in programmed cell death by acting as a molecular switch for apoptosis, necroptosis and pyroptosis, and is required to prevent tissue damage during embryonic development and adulthood. Initiator protease that induces extrinsic apoptosis by mediating cleavage and activation of effector caspases responsible for FAS/CD95-mediated and TNFRSF1A-induced cell death. Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. Binding to the adapter molecule FADD recruits it to either receptor FAS/TNFRSF6 or TNFRSF1A. The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. 1. Blasche, S. et al. (2013) PloS one 8, e58937. PMID: 23516580 2. Peng, T. et al. (2022) Molecular cell 82, 1806-1820.e8. PMID: 35338844 3. Liu, Y. et al. (2022) mBio 13, e0069022. PMID: 35446120 4. Boldin, MP. et al. (1996) Cell 85, 803-15. PMID: 8681376 5. Muzio, M. et al. (1996) Cell 85, 817-27. PMID: 8681377 6. Srinivasula, SM. et al. (1996) Proceedings of the National Academy of Sciences of the United States of America 93, 14486-91. PMID: 8962078 7. Muzio, M. et al. (1997) The Journal of biological chemistry 272, 2952-6. PMID: 9006941 8. Medema, JP. et al. (1997) The EMBO journal 16, 2794-804. PMID: 9184224 9. Denault, JB. et al. (2006) Molecular cell 23, 523-33. PMID: 16916640 10. Tao, P. et al. (2020) Nature 577, 109-114. PMID: 31827280 | ||||||||
| 注意事項 | For research use only. |
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