Anti-Cav1.2/1.3 Ca2+ channel Recombinant Antibody (L57/46) (HX048023)

Name: Anti-Cav1.2/1.3 Ca2+ channel Recombinant Antibody (L57/46)
Brand: abinScience
SKU: HX048023
Price: 110 USD
Availability: InStock

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Aperçu
Images
Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HX048023

Reactivité des espèces

Human, Mouse, Rat

Applications

IHC, WB

Espèce hôte

Mouse

Clonalité

Monoclonal

Isotype

IgG2a, kappa

ID de clone

L57/46

Cible

Calcium channel, L type, alpha-1 polypeptide, isoform 2, Voltage-gated calcium channel subunit alpha Cav1.3, Voltage-dependent L-type calcium channel subunit alpha-1D, CCHL1A2, CACNA1D, CACN4, CACNL1A2, CACH3

Niveau d'endotoxines

Please contact with the lab for this information.

Pureté

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Numéro d'accès

Q13936, Q01815, P22002

RRID

Anti-Cav1.2/1.3 Ca2+ channel Antibody (L57/46) (abinScience Cat# HX048023, RRID:AB_3728316)
_x005F_x005F_x000D_

Forme

Liquid

Tampon de stockage

0.01M PBS pH 7.4

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Contexte

Voltage-dependent L-type calcium channel subunit alpha-1C (Cav1.2/1.3 Ca2+ channel) is a ~248 kDa protein. Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine.

1. Qin, N. et al. (2002) Molecular pharmacology 62, 485-96. PMID: 12181424

2. Splawski, I. et al. (2004) Cell 119, 19-31. PMID: 15454078

3. Splawski, I. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 8089-96; discussion 8086-8. PMID: 15863612

4. Van Petegem, F. et al. (2005) Nature structural & molecular biology 12, 1108-15. PMID: 16299511

5. Antzelevitch, C. et al. (2007) Circulation 115, 442-9. PMID: 17224476

6. Kim, EY. et al. (2010) The EMBO journal 29, 3924-38. PMID: 20953164

7. Boczek, NJ. et al. (2013) Circulation. Cardiovascular genetics 6, 279-89. PMID: 23677916

8. Fukuyama, M. et al. (2014) Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 16, 1828-37. PMID: 24728418

9. Boczek, NJ. et al. (2015) Circulation. Arrhythmia and electrophysiology 8, 1122-32. PMID: 26253506

10. Sutphin, BS. et al. (2016) Congenital heart disease 11, 683-692. PMID: 27218670

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Cav1.2/1.3 Ca2+ channel Antibody (L57/46)

Reférences

Fiche technique

Anti-Cav1.2/1.3 Ca2+ channel Recombinant Antibody (L57/46).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

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