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| カタログ番号 | HB037014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-CBR1 Polyclonal Antibody (HB037014) is a rabbit polyclonal antibody detecting CBR1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CBR1 (Met1-Trp277). | ||||||||
| ターゲット | CBR1, CRN, Prostaglandin 9-ketoreductase, Carbonyl reductase [NADPH] 1, Short chain dehydrogenase/reductase family 21C member 1, PG-9-KR, Prostaglandin-E(2) 9-reductase, 15-hydroxyprostaglandin dehydrogenase [NADP(+)], NADPH-dependent carbonyl reductase 1, CBR, 20-beta-hydroxysteroid dehydrogenase, SDR21C1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P16152 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Carbonyl reductase [NADPH] 1 (CBR1) is a ~30 kDa protein. NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. 1. Tanaka, M. et al. (2005) PLoS biology 3, e128. PMID: 15799708 2. Gonzalez-Covarrubias, V. et al. (2007) Drug metabolism and disposition: the biological fate of chemicals 35, 973-80. PMID: 17344335 3. Bateman, R. et al. (2007) Organic & biomolecular chemistry 5, 3363-7. PMID: 17912391 4. Gonzalez-Covarrubias, V. et al. (2008) Pharmaceutical research 25, 1730-4. PMID: 18449627 5. Bateman, RL. et al. (2008) The Journal of biological chemistry 283, 35756-62. PMID: 18826943 6. Forrest, GL. et al. (1991) Molecular pharmacology 40, 502-7. PMID: 1921984 7. Wermuth, B. (1981) The Journal of biological chemistry 256, 1206-13. PMID: 7005231 8. Morgan, RA. et al. (2017) Scientific reports 7, 10633. PMID: 28878267 | ||||||||
| 注意事項 | For research use only. |
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