

| Каталожный номер | HB037014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-CBR1 Polyclonal Antibody (HB037014) is a rabbit polyclonal antibody detecting CBR1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Реактивность видов | Human | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human CBR1 (Met1-Trp277). | ||||||||
| Цель | CBR1, CRN, Prostaglandin 9-ketoreductase, Carbonyl reductase [NADPH] 1, Short chain dehydrogenase/reductase family 21C member 1, PG-9-KR, Prostaglandin-E(2) 9-reductase, 15-hydroxyprostaglandin dehydrogenase [NADP(+)], NADPH-dependent carbonyl reductase 1, CBR, 20-beta-hydroxysteroid dehydrogenase, SDR21C1 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | P16152 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Carbonyl reductase [NADPH] 1 (CBR1) is a ~30 kDa protein. NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. 1. Tanaka, M. et al. (2005) PLoS biology 3, e128. PMID: 15799708 2. Gonzalez-Covarrubias, V. et al. (2007) Drug metabolism and disposition: the biological fate of chemicals 35, 973-80. PMID: 17344335 3. Bateman, R. et al. (2007) Organic & biomolecular chemistry 5, 3363-7. PMID: 17912391 4. Gonzalez-Covarrubias, V. et al. (2008) Pharmaceutical research 25, 1730-4. PMID: 18449627 5. Bateman, RL. et al. (2008) The Journal of biological chemistry 283, 35756-62. PMID: 18826943 6. Forrest, GL. et al. (1991) Molecular pharmacology 40, 502-7. PMID: 1921984 7. Wermuth, B. (1981) The Journal of biological chemistry 256, 1206-13. PMID: 7005231 8. Morgan, RA. et al. (2017) Scientific reports 7, 10633. PMID: 28878267 | ||||||||
| Примечание | For research use only. |
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