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| カタログ番号 | HF500014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-CBR3 Polyclonal Antibody (HF500014) is a rabbit polyclonal antibody detecting CBR3 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CBR3 (Met1-Trp277). | ||||||||
| ターゲット | Carbonyl reductase [NADPH] 3, Short chain dehydrogenase/reductase family 21C member 2, NADPH-dependent carbonyl reductase 3, CBR3 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O75828 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Carbonyl reductase [NADPH] 3 (CBR3) is a ~30 kDa protein. Catalyzes the NADPH-dependent reduction of carbonyl compounds to their corresponding alcohols. Has low NADPH-dependent oxidoreductase activity. Acts on several orthoquinones, acts as well on non-quinone compounds, such as isatin or on the anticancer drug oracin. Best substrates for CBR3 is 1,2- naphthoquinone, hence could play a role in protection against cytotoxicity of exogenous quinones. Exerts activity toward ortho-quinones but not paraquinones. 1. Miura, T. et al. (2008) Molecular and cellular biochemistry 315, 113-21. PMID: 18493841 2. Lakhman, SS. et al. (2005) Drug metabolism and disposition: the biological fate of chemicals 33, 254-7. PMID: 15537833 3. Pilka, ES. et al. (2009) PloS one 4, e7113. PMID: 19841672 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-CBR3 polyclonal antibody at 1μg/ml on various samples.
Lane 1: MCF7 cell lysate
Lane 2: Mouse ovary lysate
Lane 3: Mouse uterus lysate
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