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| カタログ番号 | HT378014 | ||||||||
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| 説明 |
Anti-CCN1 Polyclonal Antibody (HT378014) is a rabbit polyclonal antibody detecting CCN1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, and Pan troglodytes.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CCN1 (Leu178-Asp381). | ||||||||
| ターゲット | Insulin-like growth factor-binding protein 10, Protein GIG1, IGF-binding protein 10, CYR61, Cellular communication network factor 1, IBP-10, Cysteine-rich angiogenic inducer 61, GIG1, Protein CYR61, CCN1, IGFBP-10, IGFBP10, CCN family member 1 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O00622 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | CCN family member 1 (CCN1/IGFBP10) is a ~42 kDa protein. Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CCN1-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. | ||||||||
| 注意事項 | For research use only. |
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