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| カタログ番号 | HB131014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-CCND2 Polyclonal Antibody (HB131014) is a rabbit polyclonal antibody detecting CCND2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Pig.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CCND2 (Met1-Leu289). | ||||||||
| ターゲット | G1/S-specific cyclin-D2, CCND2 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P30279 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | G1/S-specific cyclin-D2 (CCND2) is a ~33 kDa protein. Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. 1. Wang, Z. et al. (2008) Cell structure and function 33, 171-83. PMID: 18827403 2. Meyerson, M. et al. (1994) Molecular and cellular biology 14, 2077-86. PMID: 8114739 | ||||||||
| 注意事項 | For research use only. |
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