Anti-Human CD106/VCAM1 Polyclonal Antibody (HB032014)

Name: Anti-Human CD106/VCAM1 Polyclonal Antibody
Brand: abinScience
SKU: HB032014
Price: 168 USD
Availability: InStock

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Reférences
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SDS

Aperçu

Numéro de catalogue

HB032014

Description

Anti-CD106/VCAM1 Polyclonal Antibody (HB032014) is a rabbit polyclonal antibody detecting VCAM1 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactivité des espèces

Human

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human CD106/VCAM1 (Phe25-Glu698).

Cible

Vascular cell adhesion protein 1, VCAM1, CD106, INCAM-100, V-CAM 1, VCAM-1

Purification

Purified by antigen affinity column.

Numéro d'accès

P19320

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Vascular cell adhesion protein 1 (CD106/VCAM1) is a ~81 kDa protein. Cell adhesion glycoprotein predominantly expressed on the surface of endothelial cells that plays an important role in immune surveillance and inflammation. Acts as a major regulator of leukocyte adhesion to the endothelium through interaction with different types of integrins. During inflammatory responses, binds ligands on the surface of activated endothelial cells to initiate the activation of calcium channels and the plasma membrane-associated small GTPase RAC1 leading to leukocyte transendothelial migration. Also serves as a quality-control checkpoint for entry into bone marrow by providing a 'don't-eat-me' stamping in the context of major histocompatibility complex (MHC) class-I presentation.

1. Li, Y. et al. (2020) Journal of molecular cell biology 12, 190-201. PMID: 31310649

2. Taooka, Y. et al. (1999) The Journal of cell biology 145, 413-20. PMID: 10209034

3. Marchese, ME. et al. (2012) Biochemistry 51, 8235-46. PMID: 22970700

4. Pinho, S. et al. (2022) Nature cell biology 24, 290-298. PMID: 35210567

Note

For research use only.

Images

Reférences

Fiche technique

Anti-Human CD106/VCAM1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

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