Anti-CD113/NECTIN3 Polyclonal Antibody (HV970014)

Name: Anti-CD113/NECTIN3 Polyclonal Antibody
Brand: abinScience
SKU: HV970014
Price: 168 USD
Availability: InStock

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Precio(USD):

Especificación:

50ug
100ug

Número:

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Datasheet
SDS

Vista general

Número de catálogo

HV970014

Descripción

Anti-CD113/NECTIN3 Polyclonal Antibody (HV970014) is a rabbit polyclonal antibody detecting NECTIN3 in ELISA, IHC, WB. Suitable for Human and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactividad de especies

Human, Mouse

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human CD113/NECTIN3 (Thr171-Ser356).

Objetivo

CDw113, PRR3, PVRL3, Poliovirus receptor-related protein 3, NECTIN3, Nectin cell adhesion molecule 3, CD113, Nectin-3

Purificación

Purified by antigen affinity column.

Número de acceso

Q9NQS3

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Nectin-3 (CD113/NECTIN3) is a ~61 kDa protein. Cell adhesion molecule that promotes cell-cell adhesion through heterophilic trans-interactions with nectins-like or other nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Involved in axon guidance by promoting contacts between the commissural axons and the floor plate cells. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses.

1. Fujito, T. et al. (2005) The Journal of cell biology 171, 165-73. PMID: 16216929

Nota

For research use only.

Imágenes

Referencias

Datasheet