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Anti-CD119/IFNGR1 Polyclonal Antibody (HB990014)

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Vista general
Número de catálogoHB990014
Descripción
Anti-CD119/IFNGR1 Polyclonal Antibody (HB990014) is a rabbit polyclonal antibody detecting IFNGR1 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactividad de especiesHuman
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human CD119/IFNGR1 (Glu18-Gly245).
Objetivo IFN-gamma-R1, Interferon gamma receptor 1, CDw119, Interferon gamma receptor alpha-chain, IFN-gamma receptor 1, IFNGR1, IFN-gamma-R-alpha, CD119
Purificación Purified by antigen affinity column.
Número de acceso P15260
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Interferon gamma receptor 1 (CD119/IFNGR1) is a ~54 kDa protein. Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Associates with transmembrane accessory factor IFNGR2 to form a functional receptor. Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to dimerization, translocation to the nucleus, and stimulation of target gene transcription.

1. van de Wetering, D. et al. (2010) Molecular immunology 47, 1023-30. PMID: 20015550
2. Thiel, DJ. et al. (2000) Structure (London, England : 1993) 8, 927-36. PMID: 10986460
3. Aguet, M. et al. (1988) Cell 55, 273-80. PMID: 2971451
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5. Walter, MR. et al. (1995) Nature 376, 230-5. PMID: 7617032
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7. Londino, JD. et al. (2017) The Biochemical journal 474, 3543-3557. PMID: 28883123
Nota For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-CD119/IFNGR1 Polyclonal Antibody

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