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Anti-CD130/IL6ST Polyclonal Antibody (HW398014)

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Vista general
Número de catálogoHW398014
Descripción
Anti-CD130/IL6ST Polyclonal Antibody (HW398014) is a rabbit polyclonal antibody detecting CD130 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactividad de especiesHuman
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human CD130/IL6ST (Thr392-Thr566).
Objetivo IL-6 receptor subunit beta, CDw130, IL-6R-beta, Membrane glycoprotein 130, CD130, Oncostatin-M receptor subunit alpha, Interleukin-6 signal transducer, IL-6RB, IL-6R subunit beta, IL6ST, Interleukin-6 receptor subunit beta, gp130
Purificación Purified by antigen affinity column.
Número de acceso P40189
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Interleukin-6 receptor subunit beta (CD130/IL6ST) is a ~103 kDa protein. Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates the intracellular JAK-MAPK and JAK-STAT3 signaling pathways. That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3. In parallel, the IL6 signaling pathway induces the expression of two cytokine receptor signaling inhibitors, SOCS1 and SOCS3, which inhibit JAK and terminate the activity of the IL6 signaling pathway as a negative feedback loop.

1. Hibi, M. et al. (1990) Cell 63, 1149-57. PMID: 2261637
2. Waetzig, GH. et al. (2010) The Journal of biological chemistry 285, 1781-9. PMID: 19915009
3. Schütt, A. et al. (2013) The Biochemical journal 450, 487-96. PMID: 23294003
4. Taniguchi, K. et al. (2015) Nature 519, 57-62. PMID: 25731159
5. Hashimoto, Y. et al. (2009) Molecular biology of the cell 20, 2864-73. PMID: 19386761
Nota For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
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Volume
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g/mol
Formula
C₁ × V₁ = C₂ × V₂
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Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-CD130/IL6ST Polyclonal Antibody

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