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| カタログ番号 | HW398014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-CD130/IL6ST Polyclonal Antibody (HW398014) is a rabbit polyclonal antibody detecting CD130 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CD130/IL6ST (Thr392-Thr566). | ||||||||
| ターゲット | IL-6 receptor subunit beta, CDw130, IL-6R-beta, Membrane glycoprotein 130, CD130, Oncostatin-M receptor subunit alpha, Interleukin-6 signal transducer, IL-6RB, IL-6R subunit beta, IL6ST, Interleukin-6 receptor subunit beta, gp130 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P40189 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Interleukin-6 receptor subunit beta (CD130/IL6ST) is a ~103 kDa protein. Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates the intracellular JAK-MAPK and JAK-STAT3 signaling pathways. That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3. In parallel, the IL6 signaling pathway induces the expression of two cytokine receptor signaling inhibitors, SOCS1 and SOCS3, which inhibit JAK and terminate the activity of the IL6 signaling pathway as a negative feedback loop. 1. Hibi, M. et al. (1990) Cell 63, 1149-57. PMID: 2261637 2. Waetzig, GH. et al. (2010) The Journal of biological chemistry 285, 1781-9. PMID: 19915009 3. Schütt, A. et al. (2013) The Biochemical journal 450, 487-96. PMID: 23294003 4. Taniguchi, K. et al. (2015) Nature 519, 57-62. PMID: 25731159 5. Hashimoto, Y. et al. (2009) Molecular biology of the cell 20, 2864-73. PMID: 19386761 | ||||||||
| 注意事項 | For research use only. |
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