Anti-CD130/IL6ST Polyclonal Antibody (HW398014)

Name: Anti-CD130/IL6ST Polyclonal Antibody
Brand: abinScience
SKU: HW398014
Price: 168 USD
Availability: InStock

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Обзор

Каталожный номер

HW398014

Описание

Anti-CD130/IL6ST Polyclonal Antibody (HW398014) is a rabbit polyclonal antibody detecting CD130 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Реактивность видов

Human

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human CD130/IL6ST (Thr392-Thr566).

Цель

IL-6 receptor subunit beta, CDw130, IL-6R-beta, Membrane glycoprotein 130, CD130, Oncostatin-M receptor subunit alpha, Interleukin-6 signal transducer, IL-6RB, IL-6R subunit beta, IL6ST, Interleukin-6 receptor subunit beta, gp130

Очистка

Purified by antigen affinity column.

Номер доступа

P40189

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Interleukin-6 receptor subunit beta (CD130/IL6ST) is a ~103 kDa protein. Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates the intracellular JAK-MAPK and JAK-STAT3 signaling pathways. That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3. In parallel, the IL6 signaling pathway induces the expression of two cytokine receptor signaling inhibitors, SOCS1 and SOCS3, which inhibit JAK and terminate the activity of the IL6 signaling pathway as a negative feedback loop.

1. Hibi, M. et al. (1990) Cell 63, 1149-57. PMID: 2261637

2. Waetzig, GH. et al. (2010) The Journal of biological chemistry 285, 1781-9. PMID: 19915009

3. Schütt, A. et al. (2013) The Biochemical journal 450, 487-96. PMID: 23294003

4. Taniguchi, K. et al. (2015) Nature 519, 57-62. PMID: 25731159

5. Hashimoto, Y. et al. (2009) Molecular biology of the cell 20, 2864-73. PMID: 19386761

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-CD130/IL6ST Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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