Anti-Human CD14 Polyclonal Antibody (HY038014)

Name: Anti-Human CD14 Polyclonal Antibody
Brand: abinScience
SKU: HY038014
Price: 168 USD
Availability: InStock

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Каталожный номер

HY038014

Описание

Anti-CD14 Polyclonal Antibody (HY038014) is a rabbit polyclonal antibody detecting CD14 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Реактивность видов

Human

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human CD14 (Thr20-Leu368).

Цель

CD14, Monocyte differentiation antigen CD14, Monocyte differentiation antigen CD14, membrane-bound form, Monocyte differentiation antigen CD14, urinary form, My23 antigen, Myeloid cell-specific leucine-rich glycoprotein

Уровень эндотоксинов

Please contact with the lab for this information.

Чистота

>90% as determined by SDS-PAGE.

Очистка

Purified by antigen affinity column.

Номер доступа

P08571

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Monocyte differentiation antigen CD14 is a ~40 kDa protein. Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-).

1. Wright, SD. et al. (1990) Science (New York, N.Y.) 249, 1431-3. PMID: 1698311

2. Kelley, SL. et al. (2013) Journal of immunology (Baltimore, Md. : 1950) 190, 1304-11. PMID: 23264655

3. Tsukamoto, H. et al. (2010) International immunology 22, 271-80. PMID: 20133493

4. Murakami, K. et al. (2012) FEBS letters 586, 319-24. PMID: 22265692

5. Haziot, A. et al. (1996) Immunity 4, 407-14. PMID: 8612135

6. Triantafilou, M. et al. (2006) The Journal of biological chemistry 281, 31002-11. PMID: 16880211

7. Estruch, M. et al. (2013) Atherosclerosis 229, 356-62. PMID: 23880187

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-Human CD14 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

Антитела

Наборы для анализа

Anti-Human CD14 Polyclonal Antibody (HY038014)

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