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| カタログ番号 | HV109014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-CD177 Polyclonal Antibody (HV109014) is a rabbit polyclonal antibody detecting CD177 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CD177 (Cys133-Ser301). | ||||||||
| ターゲット | CD177, NB1 GP, HNA-2a, Human neutrophil alloantigen 2a, NB1, PRV-1, CD177 antigen, Polycythemia rubra vera protein 1, NB1 glycoprotein, PRV1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q8N6Q3 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | CD177 antigen is a ~46 kDa protein. In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18, mediates activation of TNF primed neutrophils including degranulation and superoxide production. In addition, by preventing beta-2 integrin internalization and attenuating chemokine signaling favors adhesion over migration. Heterophilic interaction with PECAM1 on endothelial cells plays a role in neutrophil transendothelial migration in vitro. However, appears to be dispensable for neutrophil recruitment caused by bacterial infection in vivo. Acts as a receptor for the mature form of protease PRTN3 allowing its display at the cell surface of neutrophils. 1. Jerke, U. et al. (2011) The Journal of biological chemistry 286, 7070-81. PMID: 21193407 2. Bai, M. et al. (2017) Blood 130, 2092-2100. PMID: 28807980 3. Sachs, UJ. et al. (2007) The Journal of biological chemistry 282, 23603-12. PMID: 17580308 4. Wang, L. et al. (2013) European journal of haematology 90, 436-7. PMID: 23461681 5. von Vietinghoff, S. et al. (2007) Blood 109, 4487-93. PMID: 17244676 6. von Vietinghoff, S. et al. (2008) Clinical and experimental immunology 152, 508-16. PMID: 18462208 7. Kuckleburg, CJ. et al. (2013) Arteriosclerosis, thrombosis, and vascular biology 33, 275-84. PMID: 23202369 | ||||||||
| 注意事項 | For research use only. |
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