

| Каталожный номер | HV513014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-CD244 Polyclonal Antibody (HV513014) is a rabbit polyclonal antibody detecting CD244 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Реактивность видов | Human | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human CD244 (Cys22-Pro229). | ||||||||
| Цель | SLAM family member 4, SLAMF4, h2B4, Signaling lymphocytic activation molecule 4, Natural killer cell receptor 2B4, NKR2B4, NAIL, NK cell type I receptor protein 2B4, CD244, NK cell activation-inducing ligand, 2B4 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q9BZW8 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Natural killer cell receptor 2B4 (CD244) is a ~41 kDa protein. Heterophilic receptor of the signaling lymphocytic activation molecule (SLAM) family; its ligand is CD48. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Acts as activating natural killer (NK) cell receptor. Activating function implicates association with SH2D1A and FYN. 1. Nakajima, H. et al. (1999) European journal of immunology 29, 1676-83. PMID: 10359122 2. Speiser, DE. et al. (2001) Journal of immunology (Baltimore, Md. : 1950) 167, 6165-70. PMID: 11714776 3. Valiante, NM. et al. (1993) The Journal of experimental medicine 178, 1397-406. PMID: 8376943 4. Eissmann, P. et al. (2005) Blood 105, 4722-9. PMID: 15713798 5. Parolini, S. et al. (2000) The Journal of experimental medicine 192, 337-46. PMID: 10934222 6. Sivori, S. et al. (2000) European journal of immunology 30, 787-93. PMID: 10741393 7. Sivori, S. et al. (2002) Proceedings of the National Academy of Sciences of the United States of America 99, 4526-31. PMID: 11917118 | ||||||||
| Примечание | For research use only. |
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