Anti-Human TRANCE/TNFSF11/RANK L Polyclonal Antibody (HT439014)

Name: Anti-Human TRANCE/TNFSF11/RANK L Polyclonal Antibody
Brand: abinScience
SKU: HT439014
Price: 96 USD
Availability: InStock

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Vista general

Número de catálogo

HT439014

Descripción

Anti-CD254/RANKL/TNFSF11 Polyclonal Antibody (HT439014) is a rabbit polyclonal antibody detecting TNFSF11 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactividad de especies

Human

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human CD254/RANKL/TNFSF11 (Tyr69-Asp317).

Aplicaciones probadas

Objetivo

ODF, TNF-related activation-induced cytokine, Osteoclast differentiation factor, TNFSF11, TRANCE, Osteoprotegerin ligand, RANKL, Tumor necrosis factor ligand superfamily member 11, Receptor activator of nuclear factor kappa-B ligand, CD254, OPGL

Nivel de endotoxinas

Please contact with the lab for this information.

Purificación

Purified by antigen affinity column.

Número de acceso

O14788

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Tumor necrosis factor ligand superfamily member 11 (CD254/RANKL) is a ~35 kDa protein. Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. CD254 is the therapeutic target of denosumab (Prolia).

1. Luan, X. et al. (2012) Journal of immunology (Baltimore, Md. : 1950) 189, 245-52. PMID: 22664871

Nota

For research use only.

Imágenes

Western blot

Western blot analysis was performed using anti-RANKL polyclonal antibody at RANKL on various samples.
Lane 1: HUVEC cell lysate
Lane 2: RAW264.7 cell lysate
Lane 3: Raji cell lysate
Lane 4: Mouse spleen lysate
Lane 5: Mouse liver lysate