

| Numéro de catalogue | HV190014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-CD280/MRC2 Polyclonal Antibody (HV190014) is a rabbit polyclonal antibody detecting CD280 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| Reactivité des espèces | Human, Mouse, Rat | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human CD280/MRC2 (Pro41-Lys505). | ||||||||
| Cible | Urokinase receptor-associated protein, MRC2, CD280, Endocytic receptor 180, KIAA0709, C-type lectin domain family 13 member E, CLEC13E, UPARAP, ENDO180, UPAR-associated protein, C-type mannose receptor 2, Macrophage mannose receptor 2, Urokinase-type plasminogen activator receptor-associated protein | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | Q9UBG0 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | C-type mannose receptor 2 (CD280/MRC2) is a ~166 kDa protein. May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. | ||||||||
| Note | For research use only. |
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