Anti-CD284/TLR4 Polyclonal Antibody (HT205014)

Name: Anti-CD284/TLR4 Polyclonal Antibody
Brand: abinScience
SKU: HT205014
Price: 168 USD
Availability: InStock

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Referencias
Datasheet
SDS

Vista general

Número de catálogo

HT205014

Descripción

Anti-CD284/TLR4 Polyclonal Antibody (HT205014) is a rabbit polyclonal antibody detecting CD284 in ELISA, IHC, WB. Suitable for Human, Pan paniscus, Papio anubis, and Pongo pygmaeus.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactividad de especies

Human

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human CD284/TLR4 (Glu24-Lys631).

Objetivo

Toll-like receptor 4, TLR4, CD284, hToll

Nivel de endotoxinas

Please contact with the lab for this information.

Purificación

Purified by antigen affinity column.

Número de acceso

O00206

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Toll-like receptor 4 (CD284/TLR4) is a ~95 kDa protein. Transmembrane receptor that functions as a pattern recognition receptor recognizing pathogen- and damage-associated molecular patterns (PAMPs and DAMPs) to induce innate immune responses via downstream signaling pathways. At the plasma membrane, cooperates with LY96 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni(2+). Mechanistically, acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Alternatively, CD14-mediated TLR4 internalization via endocytosis is associated with the initiation of a MYD88-independent signaling via the TICAM1-TBK1-IRF3 axis leading to type I interferon production.

1. Arbour, NC. et al. (2000) Nature genetics 25, 187-91. PMID: 10835634

2. Bulut, Y. et al. (2005) The Journal of biological chemistry 280, 20961-7. PMID: 15809303

3. Jung, SB. et al. (2006) Infection and immunity 74, 2686-96. PMID: 16622205

4. Georgel, P. et al. (2007) Virology 362, 304-13. PMID: 17292937

5. Kim, F. et al. (2007) Circulation research 100, 1589-96. PMID: 17478729

6. Stewart, CR. et al. (2010) Nature immunology 11, 155-61. PMID: 20037584

7. Schmidt, M. et al. (2010) Nature immunology 11, 814-9. PMID: 20711192

8. Estruch, M. et al. (2013) Atherosclerosis 229, 356-62. PMID: 23880187

9. Tatematsu, M. et al. (2016) Journal of immunology (Baltimore, Md. : 1950) 196, 3865-76. PMID: 27022195

10. Xiahou, Z. et al. (2017) Nature communications 8, 950. PMID: 29038465

Nota

For research use only.

Imágenes

Referencias

Datasheet

Anti-CD284/TLR4 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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