Anti-CD284/TLR4 Polyclonal Antibody (HT205014)

Name: Anti-CD284/TLR4 Polyclonal Antibody
Brand: abinScience
SKU: HT205014
Price: 168 USD
Availability: InStock

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SDS

Aperçu

Numéro de catalogue

HT205014

Description

Anti-CD284/TLR4 Polyclonal Antibody (HT205014) is a rabbit polyclonal antibody detecting CD284 in ELISA, IHC, WB. Suitable for Human, Pan paniscus, Papio anubis, and Pongo pygmaeus.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human CD284/TLR4 (Glu24-Lys631).

Cible

Toll-like receptor 4, TLR4, CD284, hToll

Niveau d'endotoxines

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Numéro d'accès

O00206

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Toll-like receptor 4 (CD284/TLR4) is a ~95 kDa protein. Transmembrane receptor that functions as a pattern recognition receptor recognizing pathogen- and damage-associated molecular patterns (PAMPs and DAMPs) to induce innate immune responses via downstream signaling pathways. At the plasma membrane, cooperates with LY96 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni(2+). Mechanistically, acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Alternatively, CD14-mediated TLR4 internalization via endocytosis is associated with the initiation of a MYD88-independent signaling via the TICAM1-TBK1-IRF3 axis leading to type I interferon production.

1. Arbour, NC. et al. (2000) Nature genetics 25, 187-91. PMID: 10835634

2. Bulut, Y. et al. (2005) The Journal of biological chemistry 280, 20961-7. PMID: 15809303

3. Jung, SB. et al. (2006) Infection and immunity 74, 2686-96. PMID: 16622205

4. Georgel, P. et al. (2007) Virology 362, 304-13. PMID: 17292937

5. Kim, F. et al. (2007) Circulation research 100, 1589-96. PMID: 17478729

6. Stewart, CR. et al. (2010) Nature immunology 11, 155-61. PMID: 20037584

7. Schmidt, M. et al. (2010) Nature immunology 11, 814-9. PMID: 20711192

8. Estruch, M. et al. (2013) Atherosclerosis 229, 356-62. PMID: 23880187

9. Tatematsu, M. et al. (2016) Journal of immunology (Baltimore, Md. : 1950) 196, 3865-76. PMID: 27022195

10. Xiahou, Z. et al. (2017) Nature communications 8, 950. PMID: 29038465

Note

For research use only.

Images

Reférences

Fiche technique

Anti-CD284/TLR4 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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