Anti-Human TREM-1 Polyclonal Antibody (HV219014)

Name: Anti-Human TREM-1 Polyclonal Antibody
Brand: abinScience
SKU: HV219014
Price: 168 USD
Availability: InStock

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概要
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概要

カタログ番号

HV219014

説明

Anti-CD354/TREM1 Polyclonal Antibody (HV219014) is a rabbit polyclonal antibody detecting TREM1 in ELISA, IHC, WB. Suitable for Human and Pongo abelii.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

種反応性

Human

アプリケーション

ELISA, IHC, WB

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

免疫原

E. coli - derived recombinant Human CD354/TREM1 (Ala21-Asn205).

ターゲット

TREM1, Triggering receptor expressed on monocytes 1, Triggering receptor expressed on myeloid cells 1, TREM-1, CD354

精製

Purified by antigen affinity column.

アクセッション番号

Q9NP99

形態

Liquid

保存バッファー

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。

製品使用情報

アプリケーション	希釈
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

安定性と保存

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Triggering receptor expressed on myeloid cells 1 (CD354/TREM1) is a ~26 kDa protein. Cell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses. Upon activation by various ligands such as PGLYRP1, HMGB1 or HSP70, multimerizes and forms a complex with transmembrane adapter TYROBP/DAP12. In turn, initiates a SYK-mediated cascade of tyrosine phosphorylation, activating multiple downstream mediators such as BTK, MAPK1, MAPK3 or phospholipase C-gamma. This cascade promotes the neutrophil- and macrophage-mediated release of pro-inflammatory cytokines and/or chemokines, as well as their migration and thereby amplifies inflammatory responses that are triggered by bacterial and fungal infections. By also promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptor (TLR) and NOD-like receptor engagement, plays a major role in the pathophysiology of acute and chronic inflammatory diseases of different etiologies including septic shock and atherosclerosis.

1. Bouchon, A. et al. (2000) Journal of immunology (Baltimore, Md. : 1950) 164, 4991-5. PMID: 10799849

2. Arts, RJ. et al. (2011) European cytokine network 22, 11-4. PMID: 21393102

3. El Mezayen, R. et al. (2007) Immunology letters 111, 36-44. PMID: 17568691

4. Read, CB. et al. (2015) Journal of immunology (Baltimore, Md. : 1950) 194, 1417-21. PMID: 25595774

5. Carrasco, K. et al. (2019) Cellular & molecular immunology 16, 460-472. PMID: 29568119

6. Radaev, S. et al. (2003) Structure (London, England : 1993) 11, 1527-35. PMID: 14656437

7. Ormsby, T. et al. (2011) Blood 118, 936-45. PMID: 21659545

8. Fortin, CF. et al. (2007) International immunology 19, 41-50. PMID: 17098818

9. Bouchon, A. et al. (2001) Nature 410, 1103-7. PMID: 11323674

注意事項

For research use only.

イメージ

参考文献

SHAP-interpretable machine learning integrating exposures and multi-omics reveals immune alterations and biomarkers in COPD–lung cancer comorbidity

データシート

Anti-Human TREM-1 Polyclonal Antibody.pdf

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Anti-Human TREM-1 Polyclonal Antibody (HV219014)

概要

イメージ

参考文献

データシート

SDS

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お問い合わせ