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| カタログ番号 | HB030014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-CD36 Polyclonal Antibody (HB030014) is a rabbit polyclonal antibody detecting CD36 in ELISA, IHC, WB. Suitable for Human and Rat.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CD36 (Leu187-Asn428). | ||||||||
| ターゲット | CD36, FAT, GPIV, Fatty acid translocase, GP4, PAS IV, Leukocyte differentiation antigen CD36, Platelet collagen receptor, Platelet glycoprotein IV, Thrombospondin receptor, Platelet glycoprotein 4, GP3B, Glycoprotein IIIb, GPIIIB, PAS-4 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 純度 | >95% as determined by SDS-PAGE. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P16671 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Platelet glycoprotein 4 (CD36) is a ~53 kDa protein. Multifunctional glycoprotein that acts as a receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on coreceptor signaling is strongly ligand specific. Cellular responses to these ligands are involved in angiogenesis, inflammatory response, fatty acid metabolism, taste and dietary fat processing in the intestine (Probable). 1. Smith, J. et al. (2008) The Journal of biological chemistry 283, 13578-85. PMID: 18353783 2. Mitchell, RW. et al. (2011) Journal of neurochemistry 117, 735-46. PMID: 21395585 3. Tran, TT. et al. (2011) The Journal of biological chemistry 286, 25201-10. PMID: 21610069 4. Hao, JW. et al. (2020) Nature communications 11, 4765. PMID: 32958780 5. Masuda, D. et al. (2009) Journal of lipid research 50, 999-1011. PMID: 18753675 6. Keller, KL. et al. (2012) Obesity (Silver Spring, Md.) 20, 1066-73. PMID: 22240721 7. Mrizak, I. et al. (2015) The British journal of nutrition 113, 1330-7. PMID: 25822988 8. Stewart, CR. et al. (2010) Nature immunology 11, 155-61. PMID: 20037584 9. Triantafilou, M. et al. (2006) The Journal of biological chemistry 281, 31002-11. PMID: 16880211 | ||||||||
| 注意事項 | For research use only. |
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