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| カタログ番号 | HB615014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-CD59 Polyclonal Antibody (HB615014) is a rabbit polyclonal antibody detecting CD59 in ELISA, IHC, WB. Suitable for Human and Pongo abelii.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CD59 (Leu26-Asn102). | ||||||||
| ターゲット | MSK21, MAC-inhibitory protein, MEM43 antigen, MAC-IP, MIN2, MIRL, HRF20, Protectin, 1F5 antigen, MIC11, MIN3, Membrane inhibitor of reactive lysis, MACIF, 20 kDa homologous restriction factor, CD59, MIN1, CD59 glycoprotein, HRF-20, Membrane attack complex inhibition factor | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P13987 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | CD59 glycoprotein is a ~14 kDa protein. Potent inhibitor of the complement membrane attack complex (MAC) action, which protects human cells from damage during complement activation. Acts by binding to the beta-haipins of C8 (C8A and C8B) components of the assembling MAC, forming an intermolecular beta-sheet that prevents incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. 1. Farkas, I. et al. (2002) The Journal of physiology 539, 537-45. PMID: 11882685 2. Meri, S. et al. (1990) Immunology 71, 1-9. PMID: 1698710 3. Okada, H. et al. (1989) Biochemical and biophysical research communications 162, 1553-9. PMID: 2475111 4. Davies, A. et al. (1989) The Journal of experimental medicine 170, 637-54. PMID: 2475570 5. Sugita, Y. et al. (1989) Journal of biochemistry 106, 555-7. PMID: 2606909 6. Bodian, DL. et al. (1997) The Journal of experimental medicine 185, 507-16. PMID: 9053451 7. Couves, EC. et al. (2023) Nature communications 14, 890. PMID: 36797260 | ||||||||
| 注意事項 | For research use only. |
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