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Anti-CD77/A4GALT Polyclonal Antibody (HV338014)

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Numéro de catalogueHV338014
Description
Anti-CD77/A4GALT Polyclonal Antibody (HV338014) is a rabbit polyclonal antibody detecting A4GALT in ELISA, IHC, WB. Suitable for Human, Pan troglodytes, and Pongo pygmaeus.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Reactivité des espècesHuman
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Human CD77/A4GALT (Gly44-Leu353).
Cible Gb3 synthase, UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase, CD77 synthase, Alpha-1, 4-N-acetylglucosaminyltransferase, Lactosylceramide 4-alpha-galactosyltransferase, Alpha4Gal-T1, Alpha-1, 4-galactosyltransferase, A4GALT1, A4GALT, Globotriaosylceramide synthase, P1/Pk synthase, A14GALT
Purification Purified by antigen affinity column.
Numéro d'accès Q9NPC4
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

Lactosylceramide 4-alpha-galactosyltransferase (CD77/A4GALT) is a ~40 kDa protein. Glycosyltransferase involved in biosynthesis of P1, P(k) and the rare NOR antigens of P1PK histo-blood group system. Catalyzes the transfer of galactose from UDP-alpha-D-galactose in an alpha1,4 linkage to lactosylceramide/beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide(d18:1(4E)) to produce globotriaosylceramide/globoside Gb3Cer (d18:1(4E)), also known as P(k) antigen or CD77. Globoside Gb3Cer/P(k)/CD77 is a root structure in biosynthesis pathway of neutral glycosphingolipids of the globo-series. Broadly expressed in cell membranes of immune cells and other tissues, Gb3Cer/P(k)/CD77 antigen may participate in mechanisms that regulate cell-cell interactions and cell differentiation. In germinal center B cells, Gb3Cer/CD77 interacts with CD19 to drive centroblast-to-centrocyte transition, B cell receptor complex assembly and T follicular helper cell differentiation.

1. Steffensen, R. et al. (2000) The Journal of biological chemistry 275, 16723-9. PMID: 10747952
2. Kojima, Y. et al. (2000) The Journal of biological chemistry 275, 15152-6. PMID: 10748143
3. Suchanowska, A. et al. (2012) The Journal of biological chemistry 287, 38220-30. PMID: 22965229
4. Kaczmarek, R. et al. (2016) Biochemical and biophysical research communications 470, 168-174. PMID: 26773500
5. Jacob, F. et al. (2018) Cancer research 78, 2952-2965. PMID: 29572228
6. Szymczak-Kulus, K. et al. (2021) The Journal of biological chemistry 296, 100299. PMID: 33460651
Note For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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Volume
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C₁ × V₁ = C₂ × V₂
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Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-CD77/A4GALT Polyclonal Antibody

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