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| カタログ番号 | HV338014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-CD77/A4GALT Polyclonal Antibody (HV338014) is a rabbit polyclonal antibody detecting A4GALT in ELISA, IHC, WB. Suitable for Human, Pan troglodytes, and Pongo pygmaeus.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CD77/A4GALT (Gly44-Leu353). | ||||||||
| ターゲット | Gb3 synthase, UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase, CD77 synthase, Alpha-1, 4-N-acetylglucosaminyltransferase, Lactosylceramide 4-alpha-galactosyltransferase, Alpha4Gal-T1, Alpha-1, 4-galactosyltransferase, A4GALT1, A4GALT, Globotriaosylceramide synthase, P1/Pk synthase, A14GALT | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9NPC4 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Lactosylceramide 4-alpha-galactosyltransferase (CD77/A4GALT) is a ~40 kDa protein. Glycosyltransferase involved in biosynthesis of P1, P(k) and the rare NOR antigens of P1PK histo-blood group system. Catalyzes the transfer of galactose from UDP-alpha-D-galactose in an alpha1,4 linkage to lactosylceramide/beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide(d18:1(4E)) to produce globotriaosylceramide/globoside Gb3Cer (d18:1(4E)), also known as P(k) antigen or CD77. Globoside Gb3Cer/P(k)/CD77 is a root structure in biosynthesis pathway of neutral glycosphingolipids of the globo-series. Broadly expressed in cell membranes of immune cells and other tissues, Gb3Cer/P(k)/CD77 antigen may participate in mechanisms that regulate cell-cell interactions and cell differentiation. In germinal center B cells, Gb3Cer/CD77 interacts with CD19 to drive centroblast-to-centrocyte transition, B cell receptor complex assembly and T follicular helper cell differentiation. 1. Steffensen, R. et al. (2000) The Journal of biological chemistry 275, 16723-9. PMID: 10747952 2. Kojima, Y. et al. (2000) The Journal of biological chemistry 275, 15152-6. PMID: 10748143 3. Suchanowska, A. et al. (2012) The Journal of biological chemistry 287, 38220-30. PMID: 22965229 4. Kaczmarek, R. et al. (2016) Biochemical and biophysical research communications 470, 168-174. PMID: 26773500 5. Jacob, F. et al. (2018) Cancer research 78, 2952-2965. PMID: 29572228 6. Szymczak-Kulus, K. et al. (2021) The Journal of biological chemistry 296, 100299. PMID: 33460651 | ||||||||
| 注意事項 | For research use only. |
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