Anti-B7-1/CD80 Polyclonal Antibody (HW630014)

Name: Anti-B7-1/CD80 Polyclonal Antibody
Brand: abinScience
SKU: HW630014
Price: 168 USD
Availability: InStock

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Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HW630014

Description

Anti-CD80 Polyclonal Antibody (HW630014) is a rabbit polyclonal antibody detecting CD80 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactivité des espèces

Human

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human CD80 (Val35-Asn242).

Cible

CD80, BB1, T-lymphocyte activation antigen CD80, CD28LG, B7, CD28LG1, LAB7, Activation B7-1 antigen, CTLA-4 counter-receptor B7.1

Purification

Purified by antigen affinity column.

Numéro d'accès

P33681

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

T-lymphocyte activation antigen CD80 (B7-1) is a ~33 kDa protein. Costimulatory molecule that belongs to the immunoglobulin superfamily that plays an important role in T-lymphocyte activation. Acts as the primary auxiliary signal augmenting the MHC/TCR signal in naive T-cells by acting as a ligand for the CD28 receptor which is constitutively expressed on the cell surface of T-cells. In turn, activates different signaling pathways such as NF-kappa-B or MAPK leading to the production of different cytokines. Also acts as an inhibitor of T-cell activation by acting as a ligand for CTLA4, a decoy receptor, thereby blocking CD28-mediated T-cell priming. In addition, CD28/CD80 costimulatory signal stimulates glucose metabolism and ATP synthesis of T-cells by activating the PI3K/Akt signaling pathway.

1. Lu, B. et al. (2024) Acta pharmacologica Sinica 45, 1214-1223. PMID: 38467718

2. Collins, AV. et al. (2002) Immunity 17, 201-10. PMID: 12196291

3. Boulougouris, G. et al. (1999) Journal of immunology (Baltimore, Md. : 1950) 163, 1809-16. PMID: 10438913

4. Vandenborre, K. et al. (1999) Immunology 98, 413-21. PMID: 10583602

5. Stamper, CC. et al. (2001) Nature 410, 608-11. PMID: 11279502

6. Frauwirth, KA. et al. (2002) Immunity 16, 769-77. PMID: 12121659

7. Kennedy, A. et al. (2023) The EMBO journal 42, e111556. PMID: 36727298

Note

For research use only.

Images

Reférences

Fiche technique

Anti-B7-1/CD80 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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