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| カタログ番号 | HC333014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-CDC20 Polyclonal Antibody (HC333014) is a rabbit polyclonal antibody detecting CDC20 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CDC20 (Gln218-Arg471). | ||||||||
| ターゲット | Cell division cycle protein 20 homolog, p55CDC, CDC20 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q12834 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Cell division cycle protein 20 homolog (CDC20) is a ~54 kDa protein. Substrate-specific adapter of the anaphase promoting complex/cyclosome (APC/C) complex that confers substrate specificity by binding to substrates and targeting them to the APC/C complex for ubiquitination and degradation. Recognizes and binds the destruction box (D box) on protein substrates. Involved in the metaphase/anaphase transition of cell cycle. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. 1. Fang, G. et al. (1998) Molecular cell 2, 163-71. PMID: 9734353 2. Lin, Z. et al. (2015) Cell discovery 1, 15028-. PMID: 27030811 3. Choppara, S. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, 998-1003. PMID: 29343641 4. Zhao, L. et al. (2020) Protein & cell 11, 921-927. PMID: 32666501 5. Kramer, ER. et al. (1998) Current biology : CB 8, 1207-10. PMID: 9811605 6. Fang, G. et al. (1998) Genes & development 12, 1871-83. PMID: 9637688 | ||||||||
| 注意事項 | For research use only. |
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