

| Número de catálogo | HB207014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Reactividad de especies | Human, Mouse, Rat | ||||||||
| Aplicaciones | ELISA, IHC, WB | ||||||||
| Especie huésped | Rabbit | ||||||||
| Clonalidad | Polyclonal | ||||||||
| Isotipo | IgG | ||||||||
| Inmunógeno | E. coli - derived recombinant Human CDC27 (Asn17-Ser231). | ||||||||
| Objetivo | ANAPC3, Cell division cycle protein 27 homolog, CDC27, APC3, Anaphase-promoting complex subunit 3, CDC27Hs, D0S1430E, CDC27 homolog, D17S978E, H-NUC | ||||||||
| Purificación | Purified by antigen affinity column. | ||||||||
| Número de acceso | P30260 | ||||||||
| Forma | Liquid | ||||||||
| Buffer de almacenamiento | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote. |
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| Información de uso del producto |
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| Estabilidad y almacenamiento | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Fondo | Cell division cycle protein 27 homolog (CDC27) is a ~91 kDa protein. Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins. 1. Jin, L. et al. (2008) Cell 133, 653-65. PMID: 18485873 2. Yau, RG. et al. (2017) Cell 171, 918-933.e20. PMID: 29033132 | ||||||||
| Nota | For research use only. |
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