Anti-C.difficile Toxin A/tcdA Recombinant Antibody (SAA1378) (JN085033)

Name: Anti-C.difficile Toxin A/tcdA Recombinant Antibody (SAA1378)
Brand: abinScience
SKU: JN085033
Price: 126 USD
Availability: InStock

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概要
イメージ
参考文献
データシート
SDS

概要

カタログ番号

JN085033

種反応性

Clostridioides difficile

アプリケーション

ELISA, Neutralization

宿主種

Human

クローン性

Monoclonal

アイソタイプ

IgG1, kappa

クローンID

SAA1378

ターゲット

Toxin A, 3.4.22.-, Glucosyltransferase TcdA, 2.4.1.-, tcdA, toxA

エンドトキシンレベル

Please contact with the lab for this information.

純度

>95% as determined by SDS-PAGE.

精製

Protein A/G purified from cell culture supernatant.

アクセッション番号

P16154

RRID

Anti-C.difficile Toxin A/tcdA Antibody (SAA1378) (abinScience Cat# JN085033, RRID:AB_3726896)
_x005F_x005F_x000D_

形態

Liquid

保存バッファー

0.01M PBS pH 7.4

データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。

製品使用情報

アプリケーション	希釈
ELISA	1:2000-1:20000

安定性と保存

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

背景

Toxin A (tcdA) is a ~308 kDa protein. Precursor of a cytotoxin that targets and disrupts the colonic epithelium, inducing the host inflammatory and innate immune responses and resulting in diarrhea and pseudomembranous colitis. TcdA and TcdB constitute the main toxins that mediate the pathology of C.difficile infection, an opportunistic pathogen that colonizes the colon when the normal gut microbiome is disrupted. Compared to TcdB, TcdA is less virulent and less important for inducing the host inflammatory and innate immune responses. This form constitutes the precursor of the toxin: it enters into host cells and mediates autoprocessing to release the active toxin (Glucosyltransferase TcdA) into the host cytosol. Targets colonic epithelia by binding to some receptor, and enters host cells via clathrin-mediated endocytosis.